Pomegranate (Punica granatum) as an adjunct in the treatment of periodontitis: An integrative literature review

Objective: The aim of this study was to conduct an integrative literature review on the effectiveness of the use of pomegranate-based products (Punica granatum) in periodontitis. Material and Methods: The collection of randomized clinical studies in humans was performed in March and August 2021 in the PubMed, Lilacs and Scielo databases, crossing the following descriptors available in the Decs: “pomegranate”, “periodontitis” and “treatment”. Results: After excluding publications in the thesis format, dissertation, book chapter, in vitro articles and those that were not related to the research theme, 2 studies were selected for full reading that were in accordance with the eligibility criteria of the present study. Conclusion: Within the limits of this study, the present integrative review evaluated that pomegranate-based products have therapeutic potential as an adjunct in the treatment of periodontitis, but more long-term clinical studies with similar methodological characteristics are still necessary to establish the effectiveness of pomegranate in the treatment of periodontitis.